Drug delivery

Drug efficacy in humans can be heavily influenced by how it interacts with various digestive system transporters. Researchers at the Massachusetts Institute of Technology (MIT), Duke University, and Brigham and Women’s Hospital have developed a method that identifies the interactions between drugs and these transporters. These interactions can potentially result in adverse effects if two…

Researchers from MIT, Brigham and Women’s Hospital, and Duke University have developed a machine-learning, multipronged strategy to identify which transporter proteins a drug uses to navigate through a patient's digestive tract. Knowledge in this area is key to improving drug efficacy and patient safety as drugs using the same transporter proteins can interfere with each…

Discovering the transporters used by specific drugs can have profound impacts on patient care, and can also inform drug development. Drugs taken orally must pass through the digestive tract, and this often happens via transporter proteins. But, it's often unknown which transporter a certain drug uses to exit the digestive tract, and this could potentially…

Researchers from MIT, Brigham and Women’s Hospital, and Duke University have pioneered a multifaceted approach to determine the transporters used by various drugs to exit the digestive tract. Leveraging tissue models and machine-learning algorithms, the team has discovered that doxycycline (an antibiotic) and warfarin (a blood thinner) can interfere with each other’s absorption. All orally consumed…

Drugs taken orally must pass through the digestive tract, aided by transporter proteins found in the lining of the tract. If two drugs use the same transporter, they can interfere with each other. Addressing this issue, a team of researchers from MIT, Brigham and Women’s Hospital, and Duke University have developed a strategy to identify…

Researchers from MIT, Brigham and Women’s Hospital, and Duke University have developed a strategy to understand how orally ingested drugs exit the digestive tract. The process relies on transporter proteins found in the lining of the digestive tract. Identifying the specific transporters used by various drugs can help avoid potential complications when two drugs using…

Oral medications must traverse the lining of the digestive tract through a process facilitated by proteins found in the cells lining the gastrointestinal tract. Researchers at MIT, Duke University, and Brigham and Women's Hospital have developed a new strategy to identify these proteins (transporters) utilized by individual drugs. This knowledge could enhance patient treatment, as…

Oral medications inevitably must travel through the digestive tract, with transporter proteins assisting this process. However, the exact transporter proteins used by numerous drugs remain unknown. Understanding these transporters could augment patient treatment significantly, given that drugs using the same transporter can disrupt each other's function and should not be co-administered. To solve this, researchers…

A novel approach developed by researchers at MIT, Brigham and Women’s Hospital, and Duke University helps identify the transporters used by various drugs to pass through the digestive tract, thus enhancing patient treatment. The method uses both tissue models and machine-learning algorithms. This can play an instrumental role in mitigating possible drug interference that occurs…