Drug delivery

Researchers from MIT, Duke University, and Brigham and Women’s Hospital have designed an innovative strategy to identify the specific transporters that different drugs utilize. The study could potentially improve patient treatment as it uncovered that certain common drugs can interfere with each other if they rely on the same transporter. The process is based upon…

Oral drugs must pass through the lining of the digestive tract to be absorbed into the bloodstream and take effect. Certain proteins present in the cells lining the digestive tract, known as transporters, aid this process, but for many drugs, the specific transporters they utilize are unknown. This knowledge could enhance patient treatment regimens as…

Researchers from MIT, Brigham and Women’s Hospital, and Duke University have developed a system using tissue models and machine-learning algorithms to identify how different drugs navigate through the lining of the digestive tract, which could have significant implications for the world of medicine. Orally-taken drugs often rely on transporter proteins within the digestive tract's cells to…

American researchers at MIT, Brigham and Women’s Hospital, and Duke University have designed an innovative approach to identifying the transporters used by different drugs that are taken orally. The strategy involves the use of both tissue models and machine-learning algorithms, and has already revealed that a commonly prescribed antibiotic and a blood thinner can interfere…

Researchers at MIT, Brigham and Women’s Hospital, and Duke University have developed a method for identifying the protein transporters different drugs use to traverse the digestive tract. This could help to avoid dangerous drug interactions and enhance patient treatment as two medications that use the same transporter may interact negatively if prescribed together. The method…