Discovering the transporters used by specific drugs can have profound impacts on patient care, and can also inform drug development. Drugs taken orally must pass through the digestive tract, and this often happens via transporter proteins. But, it's often unknown which transporter a certain drug uses to exit the digestive tract, and this could potentially…
Researchers from MIT, Brigham and Women’s Hospital, and Duke University have pioneered a multifaceted approach to determine the transporters used by various drugs to exit the digestive tract. Leveraging tissue models and machine-learning algorithms, the team has discovered that doxycycline (an antibiotic) and warfarin (a blood thinner) can interfere with each other’s absorption.
All orally consumed…
Drugs taken orally must pass through the digestive tract, aided by transporter proteins found in the lining of the tract. If two drugs use the same transporter, they can interfere with each other. Addressing this issue, a team of researchers from MIT, Brigham and Women’s Hospital, and Duke University have developed a strategy to identify…
Researchers from MIT, Brigham and Women’s Hospital, and Duke University have developed a strategy to understand how orally ingested drugs exit the digestive tract. The process relies on transporter proteins found in the lining of the digestive tract. Identifying the specific transporters used by various drugs can help avoid potential complications when two drugs using…
Oral medications must traverse the lining of the digestive tract through a process facilitated by proteins found in the cells lining the gastrointestinal tract. Researchers at MIT, Duke University, and Brigham and Women's Hospital have developed a new strategy to identify these proteins (transporters) utilized by individual drugs. This knowledge could enhance patient treatment, as…
Oral medications inevitably must travel through the digestive tract, with transporter proteins assisting this process. However, the exact transporter proteins used by numerous drugs remain unknown. Understanding these transporters could augment patient treatment significantly, given that drugs using the same transporter can disrupt each other's function and should not be co-administered.
To solve this, researchers…
A novel approach developed by researchers at MIT, Brigham and Women’s Hospital, and Duke University helps identify the transporters used by various drugs to pass through the digestive tract, thus enhancing patient treatment. The method uses both tissue models and machine-learning algorithms. This can play an instrumental role in mitigating possible drug interference that occurs…
Researchers from MIT, Brigham and Women’s Hospital, and Duke University have developed a system that identifies the transporters used by different drugs to exit the digestive tract. This can help improve drug treatment as it shows which medications could potentially interfere with one another. It also enables drug developers to increase drug absorbability by creating…
A team of researchers at MIT, Brigham and Women’s Hospital, and Duke University have developed a method to identify the transport proteins that specific drugs use to leave the digestive tract. This is particularly important because drugs that use the same transport protein can interfere with each other's function.
Understand the workings of these transporters could…