School of Engineering

Drug efficacy in humans can be heavily influenced by how it interacts with various digestive system transporters. Researchers at the Massachusetts Institute of Technology (MIT), Duke University, and Brigham and Women’s Hospital have developed a method that identifies the interactions between drugs and these transporters. These interactions can potentially result in adverse effects if two…

Researchers from MIT, Brigham and Women’s Hospital, and Duke University have developed a machine-learning, multipronged strategy to identify which transporter proteins a drug uses to navigate through a patient's digestive tract. Knowledge in this area is key to improving drug efficacy and patient safety as drugs using the same transporter proteins can interfere with each…

Discovering the transporters used by specific drugs can have profound impacts on patient care, and can also inform drug development. Drugs taken orally must pass through the digestive tract, and this often happens via transporter proteins. But, it's often unknown which transporter a certain drug uses to exit the digestive tract, and this could potentially…

Researchers from MIT, Brigham and Women’s Hospital, and Duke University have pioneered a multifaceted approach to determine the transporters used by various drugs to exit the digestive tract. Leveraging tissue models and machine-learning algorithms, the team has discovered that doxycycline (an antibiotic) and warfarin (a blood thinner) can interfere with each other’s absorption. All orally consumed…